Pharmacological Role of Anions (Sulphate, Nitrate, Oxalate and Acetate) on the Antibacterial Activity of Cobalt(II), Copper(II) and Nickel(II) Complexes With Nicotinoylhydrazine-Derived ONO, NNO and SNO Ligands

摘要

Mixed ligands biologically active complexes of cobalt(II), copper(II) and nickel(II) withnicotinoylhydrazine-derived ONO, NNO and SNO donor schiff-base ligands having thesame metal ion but different anions such as sulphate, nitrate, oxalate and acetate have beensynthesised and characterised on the basis of their physical, analytical and spectral data. Inorder to evaluate the role of anions on their bioability, these ligands and their synthesisedmetal complexes with various anions have been screened against bacterial species such asEscherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and the title studies have proved a definative role of anions in increasing the biological activity